Nowadays tourism sphere as the component of national economy gains increasing importance in Ukraine and is quickly integrating into the global tourism industry. Its development influences such economy sectors as transport, agriculture, communication, construction and trade and is one of the most perspective directions of structural economy reorientation in several Ukrainian regions. However, in order to create efficient tourism product and to provide qualitative tourism services, many tourism companies have to attract additional resources, which can be combined in tourism clusters. Therefore, forming of tourism clusters in Ukrainian regions is of utmost importance nowadays. The paper aims to define the role of trade in goods and services in forming of tourism cluster. The paper outlines the nature of cluster approach to forming of tourism cluster in a region. The structure of tourism clusters in a region is defined. Inter-branch links between companies of various economic activity types that are necessary for forming of tourism cluster in a region are found. Directions of interaction of wholesale-retail trade in goods and services and their role in forming of forest industry cluster are examined. The role of tourism clusters in improvement of regions’ competitive ability is emphasized. Tourism clusters are proven to have all the preconditions to be introduced at Ukrainian territory, where their major aim is to provide qualitative services to consumers. Forming and development of tourism cluster contributes to more efficient use of available resources of regions, improvement of quality and competitiveness of goods and services in tourism sphere and meeting the needs of domestic market, promoting the state policy in the sphere of tourism and resorts. Trade in goods and services takes an important place in forming of regional tourism clusters, as far as the tourism inner economic nature stipulates that a tourist necessarily spends money at the territory of vacation by buying relevant goods and services. Forming of cluster as a specialized organization of tourism sphere development not only boosts the development of tourism companies and those operating within a cluster, but also impacts the economic, social and ecological development of the territory where the cluster is formed, i.e. there is an impact effect from tourism cluster establishment.