The purpose of the article is to determine the chemical industry regional peculiarities, to identify the main trends and the prior promoting directions of chemical production development regional policy. A cluster analysis of the regions has been carried out basing on the chemical industry development potential. According to the cluster analysis results the regions have been divided into three clusters: a cluster with a high level of chemical industry development, a cluster with potential for the chemical industry development, a cluster with a low level of chemical industry development. The trends of chemical industry regional development in the temporal aspect are established. The changes in the chemical industry regional structure during 2012-2017 are researched. The chemical industry regional development in-depth analysis is performed by comparing the cluster analysis results with the chemical production centers location features. According to the results of the study three categories of regions are defined: areas with stable development, which use existing potential; areas that do not use potential enough; low-promising regions with a weak raw material base and low economic potential. Particular attention is paid to the regions of the second group; the regions’ strengths, which are formed predominantly due to the raw material base, as well as the main economic, environmental and political reasons for weakening the positions of «unstable» areas are determined. The grouping made it possible to identify prior directions of assistance to the chemical industry regional development in Ukraine. Using of existing competitive advantages (supply with own raw materials, dominant positions in the domestic market, availability of production capacities) is established as a prerequisite for the chemical industry development for the regions of the 1st and 2nd groups. At the same time, further successful development of these areas looks possible only via providing innovation and investment activity at both the local and national levels through the formation of a favorable legal and economic climate, creation of the scientific and technical infrastructure and provision of the tax, financial and other preferences.