The article reveals the role of the sports and health domains in achieving the sustainable development goals and substantiates the organizational and economic mechanism of sustainable development of the sports and health domains in the regions. The article emphasizes that Ukraine has joined the process of promoting sustainable development, which involves improving the quality of life of people, creating a more ecologically friendly environment, improving the safety of life, and improving the health of the population. The author proves that today the capacity of the sports and health domains in the socio-economic development of the regions and ensuring its sustainability is not fully used in Ukraine. This is largely due to inefficient mechanisms for managing the industry, which are not adapted to the conditions of market relations and the decentralization of powers to coordinate and regulate its development. To overcome this situation and build sports and health infrastructure in the region, it is first appropriate to create a favorable environment for the development of entrepreneurship in sports and health; use the practice of participatory budgeting and gender budgeting; support inclusive sports in the region. It is also important to establish cooperation between the authorities, NGOs, and the community. The essence and components of the organizational and economic mechanism of sustainable development of sports and health in the region are revealed. The principles necessary to be observed to maintain the sustainable development of sports in the region are offered, including consistency, transparency, balance, inclusiveness of gender equality, environmental friendliness. Attention is drawn to the importance of adherence to an inclusive approach as a tool to achieve sustainable development of sports and health in the region, which stipulates involving the population in physical activity and a healthy lifestyle, creating equal conditions to meet sports needs, and gender equality. 

sustainable development, sports and health domains, region, organizational and economic mechanism, sustainable development goals, inclusive growth