The article examines the nature of bilateral cooperation between entrepreneurship and security. On the one hand, security is an element of the business infrastructure necessary for its successful operation and development. On the other hand, it is an area of entrepreneurial activity in the field of services, which in turn can be detailed into specific types of security services. The aspects of security threats were identified and classified, including the most important of them – economic and social. The economic aspect of security is to reduce the negative consequences for sustainable development of economic actors. The social aspect is to ensure social stability in society and the freedom to exercise constitutional rights of an individual. Accounting of economic and social aspects of security by the state is necessary for the fulfillment of tasks in the field of economic regulation and social policy. Irrationality of the thinking of individual businessmen, political instability in the state and inconsistency of the legal and regulatory framework for the conduct of entrepreneurial activity in the conditions of transition to new forms of public administration can generate a number of security problems in business, which, above all, exacerbate the problem of ensuring the state national security. The gradual development of Ukrainian economy in a market environment can be carried out only with the effective functioning of the infrastructure entrepreneurship of special units, whose activities are aimed at reducing various factors of the threat that impede the success of the business. Country experience with a developed market economy shows that prevention threats and elimination of their factors is today a necessary element of infrastructure development of entrepreneurial activity and forming of favorable business sector. The development of security as an area of entrepreneurship led to two interconnected factors. First, the activation of various threat factors in the sectors of national economy has led to growth demand for services to prevent them. Secondly, the regulations adopted in recent years by the state establish the legal framework of entrepreneurial activity in the field of security. At the same time, there are a number of factors, which impede the further successful provision of industry needs of national economy for security services. The most important among them is the non-compliance of the existing organizational and economic mechanism of entrepreneurship to the current requirements of the market economy in the field of security.