The article presents methodological approaches to the regulation of remuneration in the context of ensuring the personnel security of enterprises at different levels of management: operational, tactical and strategic. Systematization of literature sources and approaches to solving the problem of regulation of remuneration in the context of human security has shown that Ukrainian and foreign scientists have investigated the issues of remuneration and personnel security, but in modern conditions there is a need to form methodological approaches to regulating remuneration precisely in the context of ensuring personnel security. The research of this issue is carried out in the following logical sequence: determination of results, formation of methodological approaches to regulation of remuneration in the context of ensuring personnel security at all levels of management: operational, tactical and strategic. The methodological toolkit of the study was: the system of economic laws, concepts and categories, the fundamental provisions of modern economic theory and applied economics. Hierarchical directions of regulation of remuneration in the context of providing personnel security at the strategic level of management are defined: reliability of senior management personnel, ability to innovate, leadership competencies, anti-conflict security, social protection of personnel. The main factors of performance management for the regulation of remuneration in the context of ensuring personnel security at all levels of management are identified. The formation of methodological approaches to the regulation of remuneration in the context of personnel security should take into account the hierarchy of measures and factors at three levels of management: operational, tactical and strategic, which will contribute to improving the effectiveness of managerial decisions in the field of labor security.