The purpose of this article is to study the essence, the main principles and peculiarities of management of transboundary water resources (TBWR), to elaborate the concept of management of TBWR, to substantiate the expediency of coordinated management of TBWR by countries sharing a transboundary water basin. The study of national water resources management issues has received considerable attention from foreign and domestic scientists. At the same time, the scientists' contribution to the study of the essence, the basic principles and peculiarities of management of transboundary water resources remains insignificant. The article substantiates the relevance of research on the basis of TBWR management by the worldwide prevalence of such resources, growing needs of the population and the economy in qualitative water resources. The objectives of TBWR management should be defined in three components: social, economic and environmental. In order to achieve the objectives, TBWR management actors at interstate, national and regional levels are expected to implement general (forecasting, planning, organization, motivation, coordination and regulation, control) and special (rulemaking, monitoring, data collection and analysis, ecocontrol, eco-expertise, accounting and cadastre, stimulation, evaluation of efficiency) functions. The main system-forming principles of TBWR management are outlined. According to the results of research analysis, an integrated approach within the river basins is determined. The necessity of application of ecological principles of economic regulation of use and protection of TBWR is substantiated. The tools for implementing the functions and principles of TSVR management are determined. The article also explores the factors that contribute, or hinder or impede the realization of TBWR management objectives. The realization of TBWR management goals will help increasing social and economic well-being of the population of neighboring countries, supporting ecologically safe environment, promoting further expansion and improvement of international cooperation in various spheres.