The aim of the article is to identify cause-and-effect relationships and assess the impact of spatial factors on the productive capacity of the regional economy. The nature of the productive capacity of the regional economy is theoretically considered, and the characteristics of spatial factors and their possible impact on the productive capacity of the regional economy are outlined. The productive capacity of the regional economy is largely determined by concentration factors; agglomeration effects, resource provision, location conditions, level of infrastructure development, management, technologies, and human capital. At the same time, the article also identifies the factors that can significantly reduce or even limit the productive capacity of the economy – administrative fragmentation, corruption, resource limitations or loss of capacity (or fertility for agricultural lands), and "breakage of economic space". An empirical analysis and assessment of the dependence between multifactor productivity and spatial factors is conducted. Correlation-regression analysis was used as a basis, which is aimed at identifying dependencies between multifactor productivity and spatial factors. The article finds that an indicative investment density has the strongest influence on factor productivity. The influence of population density indicators and the level of population urbanization is revealed. Quantitative dependencies are established between factor productivity and indicators of real estate value in cities-regional centers of Ukraine, business density, and employment in the regions. A very weak influence of the level of education and the level of infrastructure development on factor productivity is emphasized. Generalization of the analysis results made it possible to trace the trend towards improving the values of factor productivity during 2013–2021. Among the studied regions, Kyiv, Dnipropetrovsk, Lviv, Odesa, and Poltava regions stand out, which, on the one hand, demonstrates a high level of concentration of human capital, investments, enterprises, and the labor market, and on the other hand, indicates a tendency towards spatial heterogeneity in the concentration and structure of economic assets and significant differences in the investment attractiveness of territories at the interregional and intraregional levels. 

productive capacity, space, region, correlation-regression analysis, spatial factors